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B2 Institute is addressing scientific Grand Challenges whose solutions require the combined expertise of a broad range of scientific fields and diverse interdisciplinary talents. The Institute is providing a non-traditional structure, enhanced by flexible and extensive conference facilities, that facilitates interaction. As part of its mission, the B2 Institute is helping the state of Arizona address its emerging challenges of extreme growth and fragile environment. The B2 Institute is building upon The University of Arizona's reputation as a trailblazer in interdisciplinary research.